Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Acid sphingomyelinase / ceramide signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SMPD1 | participates_in | gene | 0.63 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Selective Acid Sphingomyelinase Modulation Therapy | 0.648 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Coenzyme Q10 Supplementation Modulates Hepatic Lipidomic Alterations and Attenua [PMID:41754105] | Go Y, Joung H, Han SY, Chung J | Nutrients | 2026 | 0 |
| SMPD1 as a Potential Prognostic Biomarker in Glioma Is Associated With an Immuno [PMID:41795144] | Xu Y, Liu X, Xu B, Li Q, Zhang L, Li C, | CNS neuroscience & therapeutic | 2026 | 0 |
| Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Ant [PMID:41824764] | Liu H, Aili A, Kuang Z, Cao L, Li Z, Sha | Advanced science (Weinheim, Ba | 2026 | 0 |
| Suspected Niemann-Pick disease type B with sea-blue histiocytosis after splenect [PMID:41791926] | Liu W, Qin L, Wang G | Journal of clinical lipidology | 2026 | 0 |
| Olipudase alfa treatment for pediatric acid sphingomyelinase deficiency in Egypt [PMID:41716780] | Arafa NA, Mahfouz A, Anwar S, Marzouk I | Molecular genetics and metabol | 2026 | 0 |
| Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment s [PMID:39825014] | Chestnykh D, Mühle C, Schumacher F, Kali | Molecular psychiatry | 2025 | 0 |
| Reduction of sphingomyelinase activity associated with progranulin deficiency an [PMID:40633679] | Boyle NR, Fox SN, Tadepalli AS, Seyfried | Neurobiology of disease | 2025 | 0 |
| Acid sphingomyelinase as a pathological and therapeutic target in neurological d [PMID:38337058] | Choi BJ, Park MH, Jin HK, Bae JS | Experimental & molecular medic | 2024 | 0 |
| Optimal Control with RdCVFL for Degenerating Photoreceptors. [PMID:38345678] | ["Wifvat K", "Camacho E", "Kawski M", "L | Bulletin of mathematical biolo | 2024 | 0 |
| The Genetic Basis, Lung Involvement, and Therapeutic Options in Niemann-Pick Dis [PMID:38397448] | Tirelli C, Rondinone O, Italia M, Mira S | Biomolecules | 2024 | 0 |
| Consensus clinical management guidelines for acid sphingomyelinase deficiency (N [PMID:37069638] | Geberhiwot T, Wasserstein M, Wanninayake | Orphanet journal of rare disea | 2023 | 0 |
| Functional screening of lysosomal storage disorder genes identifies modifiers of [PMID:37200393] | Yu M, Ye H, De-Paula RB, Mangleburg CG, | PLoS genetics | 2023 | 0 |
| Case report: The spectrum of SMPD1 pathogenic variants in Hungary. [PMID:37347058] | ["Molnar M", "Szlepak T", "Cs\u00fcrke I | Frontiers in genetics | 2023 | 0 |
| The Niemann-Pick type diseases - A synopsis of inborn errors in sphingolipid and [PMID:37003582] | Pfrieger FW | Progress in lipid research | 2023 | 0 |
| Compound Heterozygote Mutation in the SMPD1 Gene Leading to Nieman-Pick Disease [PMID:36333862] | ["Kav\u010di\u010d A", "Homan M", "\u017 | The American journal of case r | 2022 | 0 |
| The COVID-19 Vaccination Still Matters: Omicron Variant Is a Final Wake-Up Call [PMID:35891234] | ["Rzymski P", "Szuster-Ciesielska A"] | Vaccines | 2022 | 0 |
| Properties of New Composite Materials Based on Hydroxyapatite Ceramic and Cross- [PMID:36012345] | ["Bartma\u0144ski M", "Ro\u015bciszewska | International journal of molec | 2022 | 0 |
| Using dynamic monitoring of choices to predict and understand risk preferences. [PMID:33234567] | ["Stillman PE", "Krajbich I", "Ferguson | Proceedings of the National Ac | 2021 | 0 |
| Clinical, biochemical, and genotype-phenotype correlations of 118 patients with [PMID:33675270] | Hu J, Maegawa GHB, Zhan X, Gao X, Wang Y | Human mutation | 2021 | 0 |
| The Kinetochore Protein Spc105, a Novel Interaction Partner of LaeA, Regulates D [PMID:31456789] | ["Zhi QQ", "He L", "Li JY", "Li J", "Wan | Frontiers in microbiology | 2020 | 0 |